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It blocks NNMT, an enzyme highly expressed in adipose tissue that methylates nicotinamide (a form of vitamin B3) into an inactive form

This molecule consists of two components bound together

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Because amylin receptors are obligate heterodimers of the calcitonin receptor with RAMP1, RAMP2 or RAMP3, the system is a standard model for studying how accessory proteins reshape the ligand binding pocket of a class B1 GPCR, and cagrilintide is used to probe that question alongside selective agonists