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Nature 227 , 561563 (1970)

The field needs validated, in vivocompatible flux sensors (O 2 , H 2 O 2 , NO/ONOO ) targeted to matrix/IMS, ER lumen, peroxisomes, plasma-membrane microdomains and nucleus, each with built-in specificity controls and reporting standards (matrix, oxygen tension, m, pH) to disambiguate signalling pulses from damage plateaus

GHSR-1a selectivity limits HPA axis activation by restricting intracellular signaling cascades primarily to pathways associated with growth hormone exocytosis rather than corticotropin release