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H 2 O 2 also mediates redox signaling through Nrf2, AMPK/PGC-1, and MAPK/ERK pathways, modulating antioxidant defense, metabolism, and cell survival ( To neutralize ROS, mitochondria use enzymatic systems including glutathione peroxidases (GPX1/4), which reduce H 2 O 2 and lipid peroxides using glutathione (GSH)

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This is because melanin production continues normally once glutathione levels drop

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Early research suggests that glucagon-like polypeptide-1 (GLP-1) blocker medications, such as Mounjaro and Wegovy, may help manage some PCOS symptoms by supporting long-term weight loss