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A graphical presentation of HS pathogenesis is demonstrated in Figure 2
doi: 10.1002/cpt.37 [DOI] [PubMed] [Google Scholar] 224.Min JS, Bae SK
Myocyte-specific inhibition of OXPHOS accelerates BCAA catabolism, leading to excessive acetyl-CoA production and lipogenesis, which then inhibits mitochondrial respiration through acetylation-mediated mechanisms, increases reactive oxygen species (ROS) production, and promotes inflammatory responses (75)
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Faje, A