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Lipopolysaccharide (LPS), TLR4, and NF-B pathway The Lipopolysaccharide (LPS) is a component of the Gram-negative bacterial outer membrane with pro-inflammatory properties

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Under the Biden administration, the Centers for Medicare and Medicaid Services (CMS) released a series of guidance documents (which were updated in 2024) on a new waiver opportunity to expand the tools available to states to address enrollee health-related social needs (or HRSN)

In some embodiments, the otic formulation or composition comprises between about 0.10% to about 5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof