The roller coaster ride to the first GLP-1 obesity drug While approved first as a drug for diabetes, very early on in its development, when Knudsen first began work on liraglutide she wondered if the same drug could also be used as a treatment of obesity (Molteni, Chen)
For the side effect phenotypes, the effect size represents log-odds ratio, whereas for the efficacy phenotype, the effect size represents percentage BMI change
Longer term follow-up from the cohorts (and when feasible RCTs) will be important to avoid underestimating the true long-term risks for harm
Outperforms Other Medications: In some studies, Mounjaro has even outperformed other injectable medications like semaglutide ( Wegovy ), showcasing its potential for effective weight management
Remember that these drugs can also be used for diabetes, but in much lower doses
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