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In CY-5 experiments, substituting Lys 27 with Ile 27 , or Lys 27 , Asn 28 with Ile 27 , Ala 28 decreased the EC 50 of both GLP-1R and GIPR, but decreased hypoglycemic efficacies in mice

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Eligibility criteria vary by study but generally require meeting BMI thresholds and having specific obesity-related conditions

Factors associated with weight loss response to GLP-1 analogues for obesity treatment: a retrospective cohort analysis