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Additionally, elevated levels of the plasma amino acid homocysteine can be a functional marker of folate, vitamin B12, or vitamin B6 deficiency, as all these vitamins are required to convert homocysteine into methionine

Food Chem Toxicol 153:112306

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Mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) overexpression is associated with tumor cell proliferation and is a novel target for drug development