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Its distinct mechanism of action is what sets it apart

"Enzyme-converted O kidneys allow ABO-incompatible transplantation without hyperacute rejection in a human decedent model." Nature Biomedical Engineering (2025): 117

Reprod Biomed Online 31(4):544556

Ongoing trials are evaluating their potential benefits in populations with type 2 diabetes mellitus and either CKD or MASLD [101,102]

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Reconstituted sema solutions for in vitro use should be prepared in phosphate-buffered saline (pH 7.4) or similar physiological buffers and held at 4C for up to one week given the compound's inherent stability