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Large-scale cardiovascular outcome trials (CVOTs) have shown that glucagon-like peptide-1 receptor agonists (GLP-1RAs) significantly reduce major adverse cardiovascular events (MACE), redefining cardiometabolic risk management and influencing contemporary therapeutic strategies

Contrary to popular belief, GLP-1 receptor agonists do not function as metabolic stimulants or significantly increase resting metabolic rate

Diabetes indications and obesity indications are often treated differently by insurance plans

Switching or combining these medicines should only be considered with qualified clinical oversight

Its role in weight loss is particularly notable, with trials showing that it surpasses the effects of both tirzepatide and semaglutide in reducing body fat

doi: 10.2337/dc12-2469 211 SingerMDeutschmanCSSeymourCWShankar-HariMAnnaneDBauerMet al