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Control group received distilled water (10 ml/kg)

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Tissue homogenates were centrifuged at 12,000 rpm at 4 C for 20 min and the supernatant was collected

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2, the NADPH homeostasis is mainly regulated by several metabolic pathways and enzymes including NAD kinase (NADK), the pentose phosphate pathway (PPP), the folate-mediated one-carbon metabolism, malic enzymes (ME), the nicotinamide nucleotide transhydrogenase (NNT), cytosolic or mitochondrial NADP-dependent isocitrate dehydrogenase (IDH1 and IDH2), the glutamine metabolism, and the fatty acid oxidation (FAO)

Autoimmune diseases, particularly Graves disease, are one of the primary causes