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however, no G6PD deficiency has been reported in this unique situation because all affected patients are heterozygotes and presumably in the blood there is overwhelming selection in favor of the cells in which the active X chromosome has the normal Gd allele

The inhibition of autophagy, which is demonstrated by diminished LC3 signal intensity (Fig

7.1.2 Zinc Zinc is regarded as an antioxidative trace element because it is a co-factor of the enzyme SOD, which scavenges free radicals

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Hence, pharmaceuticals that target the NRF2 pathway can influence multiple pathways involved in the neurodegenerative process, and therefore hold potential to become therapies that can significantly modify the course of neurodegenerative diseases

Br J Clin Pharmacol 1980;10 Suppl 2:291S-8S