They can cause a wide range of muscle-related adverse events, including myalgia, myopathy and statin-induced rhabdomyolysis, known collectively as statin-associated musculoskeletal symptoms (SAMS)
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In children, symptoms can include diarrhoea , vomiting or a failure to gain weight
However, early tBHQ research demonstrated that the addition of tBHQ increases NRF2-mediated transcription and confers neuroprotection from glutamate-induced oxidative damage (Shih et al., 2003
While inadequate nutrition can have some of the greatest impacts during the infancy phase of postnatal linear growth (the first 2 years of life), proper nutrition is essential for all stages of linear growth continuing from 2 years of life past the onset of puberty [104106]
Despite that, the acquisition of this ratio requires obtaining both blood and CSF albumin, limiting the use of this BBBP biomarker (161)