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To understand the comparison, you have to look at their structural origins

Extracts of Houttuynia cordata , Nelumbo nucifera G

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10.1111/j.1472-8206.2007.00468.x 31 Prado-VelascoM.BorobiaA.Carcas-SansuanA

Significance is indicated with asterisks * and a minimum P value of 0.05 was considered statistically significant (refer to figure legends for details)

Some professionals claim that this type of synthetic folate may even cause a build-up in the body, leading to toxicity