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Progress with obesity continues

But the new report suggests that the real-world efficacy is not as promising as clinical trial data would suggest

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The care team can review symptoms, outside labs, prior treatment plans, and whether a same-day B12 shot is appropriate before treatment is given

Because a recommendation to reduce portion sizes may be interpreted differently by different patients, one approach is to advise patients to reduce the portion size to an amount that leads to satiation with no GI AEs or by a specific numerical figure (eg 50%)