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Do not shake the vial

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Peer review Peer review information Nature Structural & Molecular Biology thanks the anonymous reviewers for their contribution to the peer review of this work

It has a strong affinity for copper ions, which are essential cofactors in enzyme processes related to tissue maintenance and repair

In the SELECT trial, patients did not enroll for the specific purpose of weight loss and received standard of care covering management of CV risk factors, including medical treatment and healthy lifestyle counseling, but without a specific focus on weight loss

Yet a poorly understood enzyme called NNMT (nicotinamide N-methyltransferase) actively depletes NAD+, converting it into inactive methyl-NAD compounds