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Their FAO suppression leads to reduced fatty acid breakdown and lipid accumulation, forming lipid-laden macrophages. These macrophages have severely impaired phagocytic function and cannot effectively clear apoptotic cells, foreign bodies, and cigarette smoke particles, further exacerbating the stability of the inflammatory microenvironment

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All other GLP-1s with FDA approval, such as Ozempic and Mounjaro, are approved for the treatment of type 2 diabetes

In addition to -cells and -cells, there is increasing evidence suggesting that other pancreatic islet cell types also express D 2 -like receptors