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However, the therapy at this dosage also led to a high incidence of side effects such as joint pain (50% of patients) and swelling in the limbs (37% of patients) [13]

Co-IP Procedure (using endogenous Co-IP as an example) Sample Preparation: Collect cells using an appropriate method and lyse them with Lysis Buffer containing suitable protease inhibitor cocktail to preserve protein-protein interactions

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Activating brown adipose tissue may alter the overall metabolic state, influencing the metabolic pathways of tumor cells and thereby inhibiting their growth

this problem may also be the reason why many large clinical trials were unable to confirm the results of smaller scale preliminary investigations