NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N1-methylnicotinamide and effectively removing it from the NAD+ salvage pathway
Method Absorption Rate Advantages Disadvantages Oral pills 1.2-40% depending on intrinsic factor Convenient, widely available Poor absorption, especially with age or GI issues Sublingual Slightly better than pills No need for intrinsic factor, easy to use Still less effective than injectable forms In-clinic IM injection Nearly 100% Highly effective, professionally administered Requires clinic visits, potential travel and waiting time At home B12 injection Nearly 100% Highly effective, convenient, no travel needed Requires training, prescription, and comfort with self-injection IV infusion 100% Immediate delivery to bloodstream Most expensive, requires professional administration For many people especially those with serious deficiencies, digestive disorders, or pernicious anemia at home B12 injection offers the sweet spot of effectiveness and convenience
Bacteriostatic Water 3ml is supplied strictly for laboratory research use only
"People who really believe that that's the power of placebo." B12 has me like —@katyperry As a geriatrician at Mount Sinai Hospital in Toronto, Sinha said he commonly tests for B12 levels in patients "when we're assessing a person for dementia or a person with balance issues." Otherwise he said it's ineffective to take B12 supplements to prevent deficiency and there are even potential risks of over-doing it
They are your primary ally in navigating the nuances of hormone therapy
If you reconstitute with sterile water, you introduce a multi-dose vial (you will draw from it multiple times) without any antibacterial protection
