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Form and Dosage Delivery Method : Oral tablet Frequency : Once daily Available Doses : 3 mg, 7 mg, and 14 mg Maximum Dose : 14 mg daily Special Administration Requirements Rybelsus has stringent dosing requirements that affect its absorption: Must be taken on an empty stomach with no more than 4 ounces of plain water Wait at least 30 minutes before eating, drinking other beverages, or taking other medications Tablets must be swallowed whole

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Comparison of the effect of native glucagon-like peptide 1 and dipeptidyl peptidase IV-resistant analogues on insulin release from rat pancreatic islets