However, the GLP-1R is also involved in adipogenesis in the periphery, which may account for this discrepancy (Challa et al., Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., 2014)
Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves
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High-fat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible mdr1a male mice
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