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While both medications have benefits for heart health, combining them might have complex effects on the cardiovascular system, particularly for people who already have heart problems or take other heart-related medications

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Effects are typically incremental rather than immediate, and they depend on individual biology, dose exposure patterns, and baseline pigmentation

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The tissue was then incubated in Hanks buffered salt solution (HBSS) containing 15 mM HEPES, 50 U/mL collagenase type II (Thermo Fisher 17101015), and 100 U/mL hyaluronidase (Sigma Aldrich H3506) at 37 C for 30 min