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1.4 Clinical manifestations The diagnosis of hypoglycemia has historically relied on Whipples triad, first described in 1938, which establishes three essential criteria: the presence of hypoglycemic symptoms, documented low plasma glucose levels, and resolution of symptoms following glucose administration

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Manage stress through evidence-based techniques such as mindfulness meditation, progressive muscle relaxation, or gentle exercise like walking or swimming

Despite the direct effects of SGLT-1 in glucose-induced GLP-1 hormone secretion, inhibition of this transporter can indirectly increase GLP-1 secretion

Meeting Highlights From the Pharmacovigilance Risk Assessment Committee (PRAC) 8-11 April 2024