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The reimbursement policy impact is substantial, with stringent prior authorization requirements and step-therapy protocols limiting access

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For information on managing common GLP-1 side effects, see our guides on semaglutide nausea and tirzepatide dosage adjustment

Consulting with a healthcare professional ensures safe use

Topiramate attenuates dural vasodilation primarily by inhibiting nitric oxide-mediated release of CGRP from preganglionic fibers of the trigeminal nerve (Akerman and Goadsby, 2005)