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however, most of these events are mild to moderate and their frequency and intensity generally decrease over time [16, 18, 20, 22, 24, 26, 28]

Hamedani M, Vatanpour H, Saadat F, Reza Khorramizaheh M, Mirshafiey A

A decelerating trajectory is biologically plausible, but without multi-year empirical data we cannot be certain which projection most closely reflects long term real-world outcomes. But she added: Overall, the study reinforces that GLP-1 receptor agonists are unlikely to produce durable weight loss if used as short term interventions without longer term management plans