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Interference with Diagnostic Tests: May affect results of certain laboratory tests, consult with laboratory personnel for appropriate interpretation

doi: 10.1172/jci.insight.169515 119 ChandraAWormserGPKlempnerMSTrevinoRPCrowMKLatovNet al

Progressive glutathione depletion across trimesters : First trimester: 36% LOWER than non-pregnant Second trimester: 55% LOWER Third trimester: 87% LOWER This generates more NAPQI at precisely the time when glutathione reserves are least able to neutralize itcreating maximum vulnerability

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Figure 3 shows no significant alteration in the docked compounds conformation after 100 ns MD simulation in reference to initial poses, suggesting that docked ligands maintained the strong interactions with essential residues in the catalytic pocket during MD simulation interval and established the formation of stable complexes

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