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One of the most interesting subplots of this story has been the rise of lower-price, off-brand alternatives

How is Retatrutide Administered

At 12 mg, TRIUMPH-4 also saw more dysesthesia (skin tingling/ numbness, 20.9% vs 8.8% at 9 mg) and more discontinuations for side effects (18.2% vs 12.2%) the extra ~2.3 points of weight loss over 9 mg is a tolerability trade-off

Developed by Eli Lilly, retatrutide is in late-stage clinical trials but not yet FDA-approved

Anyone with a body mass index of 30 or more, which is defined as obesity, qualifies for consideration of these medications, says Kushner