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Overall, our integrative analysis not only elucidates a previously unrecognized regulatory axis in lipedema but also provides a mechanistic framework for biomarker discovery and targeted therapy development, aligning with the core translational goals of precision medicine

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Collection and use of human ascites fluid, ascites-derived cells, and ovarian tumor tissue for organoid generation were approved by the Duke University Institutional Review Board, and written informed consent was obtained from all participants prior to sample collection