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10.1093/ehjci/jex012 105

Importantly, BPC-157s anti-inflammatory mechanisms operate differently from NSAIDs, which have been shown to impair tendon healing when used chronically

The same phenomenon also occurs in cuproptosis [146]

This is particularly relevant because so many injuries (chronic Achilles tendinopathy, rotator cuff tears) occur in areas with inherently limited blood flow

Inflammation-mediated Trp metabolic disruption, E/I imbalance, and neurotransmitter pathway dysfunction may represent central pathological mechanisms in the development of EDC