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Landmark trials include STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
For example, type 2 diabetes increases FA uptake and oxidation in the heart ( FABP3 , which mediates FA transmembrane trafficking, was downregulated, while CPT1 , which mediates mitochondrial transport and -oxidation, was upregulated
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Sermorelin's 29-residue chain provides a larger hydrodynamic radius, slower diffusion coefficient, and greater susceptibility to adsorption on container surfaces (particularly at low concentrations)