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Dosing frequency must account for the pharmacokinetic clearance (how often you need to re-activate receptors) rather than the pharmacodynamic persistence (how long you see visible effects)

One area of investigation involves the relationship between obesity, metabolic syndrome, and sexual dysfunction

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2023 Mar 30;12(4):836

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Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function