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In a 12-week, randomized, doubleblind, placebocontrolled crossover trial of weekly 1.0 mg semaglutide in adults with obesity, participants reduced total daily energy intake by about 24% and lost an average of 5 kg compared to placebo

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2.5 Altered autophagy mechanism (and role of GBA1 gene) Autophagy is a process that in normal conditions maintains cellular balance by recycling proteins and organelles, and acts as an adaptive mechanism that helps cells survive under stressful conditions

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Many participants also experienced reduced waist size and improved blood pressure