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TL;DR Contrave vs Wegovy at a Glance Wegovy (semaglutide) and Contrave (naltrexone/bupropion) are both FDA-approved medications for chronic weight management, but they differ sharply in results, mechanism, and cost

The most important thing is matching your expectations to reality

For example, papers from Khavinson and colleagues reported lower mortality and improved health outcomes in older populations treated with thymalin and epithalamin over multi-year periods, including older adults in institutional settings and elderly patients with coronary disease

Mar 2012;26(3):608-610

Patients start at lower doses and gradually increase up to this target dose

Physical activity: 150300 min/week moderate-intensity