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The addition of Siberian rhubarb and a probiotic in a menopause supplement to support physical symptoms as well as mood is unique,48 and research supports their inclusion in Fan Club.49 89 HUM funded a randomized, double-blind, placebo-controlled clinical study to investigate Fan Clubs impacts on perimenopausal women at an independent, third-party research lab.50 Menopause symptoms were decreased in 90% of participants, and 87% had fewer hot flashes