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32 It also significantly reduced the secondary composite HF endpoint (cardiovascular death, HF hospitalisation or urgent HF hospital visit), with an RRR of 18%

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ICAM, intracellular adhesion molecules

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These drugs also activate GLP-1 receptors in the hypothalamus, which increases the release of anorexigenic peptides like pro-opiomelanocortin while reducing the release of orexigenic peptides like neuropeptide Y and agouti-related peptide