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Most high-quality research shows clear differences in average weight loss: Tirzepatide (Zepbound) In large clinical trials (SURMOUNT-1), tirzepatide produced 15% to 22.5% total body weight loss , depending on the dose4

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4a , one of the initial hits, inhibited GSTO1 enzyme activity with a half-maximal inhibitory concentration (IC 50 ) value of 3.1 M