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Along with there being no reports of it causing birth defects, cancers or any other type of toxicity, Vitamin B12 doesnt even have an established tolerable upper intake level (UL), which is the amount that would cause an overdose or major unwanted side effects
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The absence of human trials means safety is uncharacterised
13 The right form of these nutrients is crucial, which is why many MTHFR patients are directed to the Methyl-Life product range
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