Treatment for B12 deficiency without neurological involvement: For patients with haematological manifestations only (macrocytic anaemia) or asymptomatic deficiency, the regimen is hydroxocobalamin 1mg intramuscularly three times weekly for two weeks (total of six injections), followed by maintenance of 1mg every three months for life
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Oral dosing is most effective for GI conditions and has demonstrated systemic effects in animal models, though bioavailability is lower than injection (Sikiric et al., 2018)
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Currently, a series of drugs that block the interaction between p53 and its negative regulators have been developed (Table 3)
Stomach issues are common with higher doses
