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For transduction, 200 l lentiviral supernatant was thawed on ice and added to HCC-1806 cells together with 8 mg ml 1 Polybrene (hexadimethrine bromide

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The hepatic iron deposition is primarily attributed to low levels of ceruloplasmin [21] , a ferroxidase that facilitates iron storage in tissues, similar to what occurs in hemochromatosis [52]