The capsaicin-induced increase in heart rate and body temperature can mimic a "thyroid storm" or a flare-up of Graves' disease symptoms
Long-term data shows that as patients stabilize on their maintenance dose and body weight plateaus, heart rate often returns closer to baseline levels
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Vomiting, Diarrhea, and Constipation Vomiting, diarrhea, and constipation were also commonly reported in retatrutide clinical trials, particularly at higher studied doses
Mechanistically, niacin enhances blood flow (via vasodilation), supports neuronal energy demands, and helps maintain cellular resilience under stress
Brand-name medications like Mounjaro and Zepbound are FDA-approved