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This kind of targeted therapy could potentially lower the number of side effects that can come with altering glutathione levels across the whole body

HOLST: Exactly

Winner for diabetes: Tirzepatide (proven Phase 3 data, FDA approval, established track record)

But then we realized it was so good & had so many benefits for people that weren't fasting it wouldn't be right just to keep it to ourselves

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions

Devalia et al., 1994)