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Clinical studies showing significant wrinkle reduction typically measured results at the 8-week mark

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[2] The study was not controlled for cream vehicle application alone without active ingredients

doi: 10.1017/S1368980021003967 [DOI] [PMC free article] [PubMed] [Google Scholar] 6.Lane MM, Davis JA, Beattie S, Gmez-Donoso C, Loughman A, O'Neil A, et al

Participants were given 5001,000 mg of vitamin C daily, which is higher than the amounts typically obtained from food