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A documented taper plan if stopping is on the table, with weight, body composition, and cardiometabolic markers tracked through the taper and for at least 12 months after

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This metabolite, known as 5-HIAA is excreted via the urine once it has undergone phase-2 glucaronidation or sulfation (see reference 5 for more detail)

52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA

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1 Approved under the brand name Zepbound in the U.S