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Kapitza, C., et al

The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

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Eating high fiber foods like oats, lentils, and vegetables supports the gut bacteria that produce short-chain fatty acids, a direct trigger for GLP-1 secretion

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids

doi: 10.1126/scitranslmed.3007218 45 OduoriOSMuraoNShimomuraKTakahashiHZhangQDouHet al