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3.3.2 MGBA and anxiety disorders Emerging evidence highlights the MGBA as a critical contributor to anxiety pathophysiology ( NCAM1, CADM2 , and PHF2/FAM120A also correlate with anxiety and mood disorders (Eijsbouts et al., 2021)

The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)

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However, H 2 O 2 can also lead to the production of the more damaging oxygen radical, OH , which can initiate a cascade of cellular injury through peroxidation of lipid, protein and DNA [24]

BMSCs: bone marrow derived mesenchymal stromal cells

However, kidney function declines with age, which affects clearance of some peptides