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Among gut-derived uremic toxins, indoxyl sulfate and p-cresyl sulfate are largely protein bound in the blood circulation (mostly to albumin) and thus poorly cleared by diffusive dialysis procedures (75)

Genetically predicted l-carnitine was associated with higher risk of CAD in men (OR 1.07, 95% CI 1.01 to 1.14) but not women (OR 1.02, 95% CI 0.96 to 1.09), although the difference by sex did not reach statistical significance ( p value for sex difference 0.31) (Fig

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