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Fistula healing is another distinctive line of research

But it points straight at something Sikiri's own lab published nearly thirty years ago

Biochemical and Biophysical Research Communications, 430(2), 614619

In two Phase 2 clinical trials covering stasis and pressure ulcers, TB4 accelerated complete wound closure by almost a month in patients who achieved full healing representing one of the most substantial healing acceleration outcomes observed for a peptide compound in a controlled clinical investigation

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Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)