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It has been hypothesized that the effects of GLP-1R agonists to reduce energy intake are at least partially driven by nausea and other GI AEs

Nausea, diarrhea, decreased appetite, and occasional vomiting are the most common side effects

While the length of these effects is unclear (Circana, 2025), these consumption changes are likely to have sweeping consequences for each grocery store, restaurant, food manufacturer, retailer, and farmer in the food system

Privacy and Discreet Care Several testimonials emphasize Brello's focus on discretion

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Cold chain storage requirements, syringe handling, injection site rotation, and the discomfort of subcutaneous administration all add friction to research protocols