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Expanding the amount and diversity of lipidomic data for patients with TBI will be necessary before changes in lipid metabolism can be considered reliable clinical biomarkers

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A Shanghai cohort study of 1,807 knee OA patients with type 2 diabetes showed GLP-1RA users had slower medial tibiofemoral cartilage loss and a reduced rate of knee surgery

The overall timeline to meaningful results should not change substantially with split dosing since total drug exposure remains equivalent