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Other studies have shown that HT generates ROS and activates the phosphatidylinositol 3-kinase/Akt pathway, leading to FOXO3a(Forkhead box O3) phosphorylation and subsequent down-regulation, which induces apoptosis in DLD1 cells 31

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When thiamine deficiency manifests with CNS involvement it is called Korsakoff encephalopathy (or Korsakoff psychosis) and is also commonly referred to as Wernicke-Korsakoff syndrome (WKS)

Understanding each pathway is essential for researchers designing targeted experimental protocols

Proceedings of 9th Annual ACVIM Forum